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Read this if you’re using Windows 2003 Scalable Networking Pack

If you're using Windows 2003 Scalable Networking Pack, make sure you see this technote, as it can have a negative impact on Sametime performance.

The Windows® 2003 Scalable Networking Pack (SNP) enables several fundamental changes to the way in which Windows Server 2003 processes network traffic. Receive Side Scaling (RSS) splits incoming network traffic among multiple CPUs, Network Direct Memory Access (NetDMA) changes how network traffic is buffered/written during processing, and TCP Chimney offloads particular networking tasks to the server's network interface card (NIC). It has been determined that these features, which are enabled by default with Service Pack 2 of Windows Server 2003, can have a negative impact on software performance, particularly for those software packages with a high transactional volume.

Link:  Domino and Sametime performance issues traced to Windows Server 2003 Scalable Networking Pack